Dr. Bruce Hoffman’s
Mold Detox Support
Protocol overview
Last updated: May 8, 2025
11 Nutrients
Quercetin
550mg
Quercetin, a potent flavonoid, may aid mold detoxification by stabilizing mast cells, reducing inflammation, and combating oxidative stress. It supports Phase II liver detoxification, including glucuronidation, potentially assisting in clearing mycotoxins like trichothecenes and ochratoxins. [1]
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Log in or sign upActivated charcoal
1000mg
Activated charcoal may assist with mold support by binding mycotoxins in the gastrointestinal tract, potentially reducing their absorption and aiding in their elimination. Its porous structure is thought to help support detoxification processes in the body. [2]
Turmeric Curcumin
2000mg
Curcumin supports detoxification and may help address mold exposure through its anti-inflammatory and antioxidant properties. It is believed to enhance liver function and assist Phase 2 glucuronidation, which processes toxins. Additionally, curcumin might contribute to immune balance and overall recovery. [3]
Resveratrol
500mg
Resveratrol may support mold toxicity recovery by enhancing liver detoxification, particularly Phase 2 glucuronidation, to process and eliminate mycotoxins. Its antioxidant and anti-inflammatory properties help reduce oxidative stress and inflammation caused by mold exposure, while promoting immune balance and cellular repair. [4]
Phosphatidylcholine
450mg
Phosphatidylcholine may assist in mold toxicity recovery by supporting cell membrane health, modulating inflammation, and promoting liver function. It also aids enterohepatic detoxification by contributing to bile production and flow, which may help eliminate fat-soluble toxins, while supporting gut integrity and reducing toxin reabsorption. [5]
N-Acetylcysteine
600mg
N-Acetylcysteine (NAC) may support recovery from mold toxicity by replenishing glutathione, the body’s primary antioxidant, to combat oxidative stress caused by mycotoxins. It aids liver detoxification, promotes toxin clearance, and modulates inflammation while supporting respiratory health and immune balance often impacted by mold exposure. [6]
Glutathione
450mg
Glutathione may aid in mold toxicity recovery by acting as a powerful antioxidant to reduce oxidative stress caused by mycotoxins. It supports liver detoxification, particularly Phase II processes, facilitates toxin elimination, and helps protect cells, mitochondria, and tissues from damage associated with mold exposure. [7]
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Warnings
Do not take if you are pregnant, breastfeeding, have a history of liver or kidney disease, or are on medications like blood thinners, immunosuppressants, or chemotherapy without consulting your healthcare provider, as interactions may occur. Take activated charcoal at least 2 hours apart from medications or supplements, as it can bind and reduce nutrient absorption.
Lifestyle Improvements
Assess Environmental Factors:
- Have a mold inspector evaluate your home for mold using visual inspection and ERMI testing.
- Complete a Visual Contrast Sensitivity (VCS) test to assess neurological function potentially impacted by toxins.
- Fill out the Chronic Inflammatory Response Syndrome (CIRS) questionnaire to identify symptoms of mold or toxin exposure.
- Perform CIRS lab testing and urine mycotoxin testing to confirm exposure and monitor progress.
Adopt a Low-Mold Lifestyle:
- Follow a low-mold diet, focusing on fresh, organic, and unprocessed foods to reduce toxin intake.
- Minimize exposure to chemicals and endocrine disruptors by reducing the use of plastics, cosmetics, and non-stick cookware.
- Decontaminate clothing and soft furnishings by washing with mold-specific cleaning agents such as Benefact or Decon 30.
Optimize Environmental and Behavioral Health:
- Create a toxin-free living space by ensuring proper ventilation and turning off Wi-Fi routers at night.
- Limit blue light exposure from devices, especially in the evening, and prioritize natural sunlight by watching the sunrise daily.
- Incorporate grounding practices by walking barefoot outdoors when possible.
- Reduce reliance on LED white light indoors to create a more supportive environment for your circadian rhythm.
Support Detoxification and Cellular Health:
- Stay well-hydrated with clean, filtered water to enhance detox pathways.
- Eat a seasonal, organic diet that supports cellular health and reduces toxin exposure.
- Ensure adequate intake of high-quality proteins and amino acids to aid Phase 2 detoxification.
- Support cell membrane integrity by consuming appropriate fatty acids and ensuring efficient methylation processes through proper nutrient intake.
Promote Stress Resilience and Well-Being:
- Practice self-regulation techniques such as mindfulness, meditation, or breathing exercises to manage stress and support overall health.
Disclaimer
These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.
While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.
- Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M. T., Wang, S., Liu, H., & Yin, Y. (2016). Quercetin, inflammation, and immunity. Nutrients, 8(3), 167. https://doi.org/10.3390/nu8030167
- Hamad, G. M., Amer, A., El-Nogoumy, B., Ibrahim, M., Hassan, S., Siddiqui, S. A., El-Gazzar, A. M., Khalifa, E., Omar, S. A., Abd-Elmohsen Abou-Alella, S., Ibrahim, S. A., Esatbeyoglu, T., & Mehany, T. (2022). Evaluation of the effectiveness of charcoal, Lactobacillus rhamnosus, and Saccharomyces cerevisiae as aflatoxin adsorbents in chocolate. Toxins (Basel), 15(1), 21. https://doi.org/10.3390/toxins15010021
- Farzaei, M. H., Zobeiri, M., Parvizi, F., El-Senduny, F. F., Marmouzi, I., Coy-Barrera, E., Naseri, R., Nabavi, S. M., Rahimi, R., & Abdollahi, M. (2018). Curcumin in liver diseases: A systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients, 10(7), 855. https://doi.org/10.3390/nu10070855
- Faghihzadeh, F., Hekmatdoost, A., & Adibi, P. (2015). Resveratrol and liver: A systematic review. Journal of Research in Medical Sciences, 20(8), 797–810. https://doi.org/10.4103/1735-1995.168405
- Maev, I. V., Samsonov, A. A., Palgova, L. K., Pavlov, C. S., Shirokova, E. N., Vovk, E. I., & Starostin, K. M. (2020). Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: Real-life observational study from Russia. BMJ Open Gastroenterology, 7(1), e000368. https://doi.org/10.1136/bmjgast-2019-000368
- Xu, P., Qu, J. M., Xu, J. F., Zhang, J., Jiang, H. N., & Zhang, H. J. (2009). NAC is associated with additional alleviation of lung injury induced by invasive pulmonary aspergillosis in a neutropenic model. Acta Pharmacologica Sinica, 30(7), 980–986. https://doi.org/10.1038/aps.2009.83
- Guilford, F. T., & Hope, J. (2014). Deficient glutathione in the pathophysiology of mycotoxin-related illness. Toxins (Basel), 6(2), 608–623. https://doi.org/10.3390/toxins6020608
- Ma, Q., Li, Y., Fan, Y., Zhao, L., Wei, H., Ji, C., & Zhang, J. (2015). Molecular mechanisms of lipoic acid protection against aflatoxin B₁-induced liver oxidative damage and inflammatory responses in broilers. Toxins (Basel), 7(12), 5435–5447. https://doi.org/10.3390/toxins7124879
- Ayyadurai, V. A. S., Deonikar, P., & Fields, C. (2023). Mechanistic understanding of D-glucaric acid to support liver detoxification essential to muscle health using a computational systems biology approach. Nutrients, 15(3), 733. https://doi.org/10.3390/nu15030733
- Rom, O., Liu, Y., Liu, Z., et al. (2020). Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. Science Translational Medicine, 12(572), eaaz2841. https://doi.org/10.1126/scitranslmed.aaz2841
- Schnedl, W. J., Schenk, M., Lackner, S., Enko, D., Mangge, H., & Forster, F. (2019). Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Science and Biotechnology, 28(6), 1779–1784. https://doi.org/10.1007/s10068-019-00627-3