Dr. Bruce Hoffman’s
Essential Cellular Health Protocol
Protocol overview
Last updated: May 13, 2025
10 Nutrients
Gamma-Linolenic Acid
250mg
Evening Primrose Oil contains gamma-linolenic acid (GLA) and linoleic acid, essential fatty acids that support cellular membrane integrity, reduce inflammation, and promote balanced skin, hormone, and immune function—key pillars of overall cellular health. [1]
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nutrient totals stack up
Log in or sign upLinoleic Acid
3143mg
Linoleic acid, an essential omega-6 fatty acid, may supports cellular health by maintaining membrane structure, enhancing skin barrier function, and regulating inflammatory pathways. It may play roles in cell signaling, immune response, and overall tissue repair and regeneration. [2]
Phosphatidylcholine
1300mg
Phosphatidylcholine is a phospholipid that supports cellular health by rebuilding and maintaining cell membrane integrity, enhancing nutrient transport, and facilitating waste removal. It also plays a role in liver function. [3]
L-Carnitine
1000mg
L-carnitine plays a role in energy production by transporting fatty acids into the mitochondria, where they are converted into ATP (energy currency of the cell). It may suppor endurance, muscle recovery, and cellular metabolism, making it essential for mitochondrial health. [4]
Alpha-Lipoic Acid
400mg
ALA is an antioxidant that supports mitochondrial function by recycling vitamins C and E and protecting against oxidative stress. It may also play a key role in energy metabolism and helps regulate blood sugar and inflammation at the cellular level. [5]
N-Acetylcysteine
1200mg
NAC is an antioxidant precursor to glutathione, the body’s master detoxifier. It may support cellular defense against oxidative stress, enhances immune function, and promotes detoxification by protecting cells from toxin-induced damage and metabolic by-products. [6]
Sodium
61mg
Sodium, as an important trace mineral, supports cellular health by regulating fluid balance, aiding nutrient transport across cell membranes, and maintaining proper nerve and muscle function. It plays a key role in cellular hydration and electrical signaling essential for energy production. [7]

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Warnings
Not recommended if you are pregnant, breastfeeding, or taking blood thinners, seizure medications, or immunosuppressants without first consulting your medical provider
Lifestyle Improvements
Prioritize nutrient density.
True mitochondrial repair and membrane regeneration require more than supplements. They demand deep nourishment. Include local organ blend capsules 4–5 days per week. These provide a rich source of bioavailable vitamins A, B12, iron, and essential peptides that support cellular respiration, detoxification, and immune function. Complement this with caviar (1–2 teaspoons, 3 times weekly) and fresh oysters (3–4 oysters, 2–3 times per week), both of which offer critical cofactors like zinc, selenium, choline, and omega-3s. These traditional foods have long been recognized for their support of energy, cognition, and tissue repair.
Hydration is more than water.
True hydration occurs when water is absorbed intracellularly, and this requires adequate electrolytes, minerals, and cell membrane function. Sip filtered mineral-rich water throughout the day, and consider structuring your water by adding trace mineral drops or a pinch of sea salt with lemon. Begin the day with a large glass of water upon waking, and avoid excess caffeine that can further deplete hydration status.
**Balance movement and stillness. **
Engage in gentle but consistent movement, such as walking, yoga, or strength training, to stimulate lymphatic flow, improve mitochondrial efficiency, and regulate circadian rhythm. Equally important is stillness. Prioritize at least 7–9 hours of restorative sleep per night, and consider mindfulness practices that downregulate the nervous system, such as meditation, breathwork, or time in nature.
**Detox through rhythm, not force. **
Avoid aggressive detox protocols unless directed. Instead, focus on supporting natural elimination pathways daily through sweating (sauna or exercise), hydration, bowel regularity, and consistent nourishment.
Lastly, approach this protocol as a dialogue. Healing is not linear, and your body’s feedback. Through energy levels, sleep, digestion, and mood is your most powerful guide. Tune in. This is the foundation upon which real transformation begins.
Disclaimer
These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.
While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.
- Timoszuk, M., Bielawska, K., & Skrzydlewska, E. (2018). Evening primrose (Oenothera biennis) biological activity dependent on chemical composition. Antioxidants, 7(8), 108. https://doi.org/10.3390/antiox7080108
- Lázaro, I., Cofán, M., Amor, A. J., Ortega, E., Freitas-Simoes, T. M., Llull, L., Amaro, S., Mestres, G., Yugueros, X., Harris, W. S., Riambau, V., & Sala-Vila, A. (2021). Linoleic acid status in cell membranes inversely relates to the prevalence of symptomatic carotid artery disease. Stroke, 52(2), 703–706. https://doi.org/10.1161/STROKEAHA.120.030477
- van der Veen, J. N., Kennelly, J. P., Wan, S., Vance, J. E., Vance, D. E., & Jacobs, R. L. (2017). The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1859(9 Pt B), 1558–1572. https://doi.org/10.1016/j.bbamem.2017.04.006
- Elantary, R., & Othman, S. (2024). Role of L-carnitine in cardiovascular health: Literature review. Cureus, 16(9), e70279. https://doi.org/10.7759/cureus.70279
- Akbari, M., Ostadmohammadi, V., Tabrizi, R., Mobini, M., Lankarani, K. B., Moosazadeh, M., Heydari, S. T., Chamani, M., Kolahdooz, F., & Asemi, Z. (2018). The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials. Nutrition & Metabolism, 15, 39. https://doi.org/10.1186/s12986-018-0274-y
- hang, F., Lau, S. S., & Monks, T. J. (2011). The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis. Toxicological Sciences, 120(1), 87–97. https://doi.org/10.1093/toxsci/kfq364
- Tako, E. (2019). Dietary trace minerals. Nutrients, 11(11), 2823. https://doi.org/10.3390/nu11112823
- Ostojic, S. M. (2015). Molecular hydrogen in sports medicine: New therapeutic perspectives. International Journal of Sports Medicine, 36(4), 273–279. https://doi.org/10.1055/s-0034-1395509
- Weaver, C. M. (2013). Potassium and health. Advances in Nutrition, 4(3), 368S–377S. https://doi.org/10.3945/an.112.003533