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GLP-1 Core Nutrient Support

Protocol overview

Compare your current stack nutrients to the outlined protocol recommendations.

This protocol is strategically designed to complement GLP-1 therapies by reinforcing physiological systems often impacted during rapid metabolic change. GLP-1 medications can reduce appetite, alter digestion, and contribute to lean muscle loss, this stack aims to restore balance by supporting energy, mood, and body composition through targeted, research-backed nutrition.

A high-quality, bioavailable protein powder forms the foundation, providing essential amino acids to help preserve muscle mass and promote satiety despite reduced food intake. It’s paired with creatine, a critical compound in ATP regeneration, which supports muscular strength, physical performance, and cognitive function. HMB, a metabolite of leucine, is included to help minimize muscle breakdown, especially useful when protein intake is low or caloric restriction is prolonged.

To further support cellular energy and metabolic adaptability, the protocol includes a full-spectrum B-complex. These essential micronutrients act as cofactors in mitochondrial function, supporting mood, stress regulation, and daily energy production. Vitamin D3 and K2 are combined to promote calcium metabolism, skeletal health, and immune function, areas that may be indirectly affected during weight loss or shifts in body composition.

Omega-3 fatty acids provide anti-inflammatory and cardiometabolic support, helping to regulate insulin sensitivity and lipid balance, important during rapid weight loss phases. Their neuroprotective and mood-supportive roles also enhance recovery and resilience.

L-Theanine rounds out the protocol with gentle, non-sedating support for nervous system regulation. By promoting calm and improving sleep quality, it helps stabilize the parasympathetic system, key for digestion, repair, and sustained metabolic health.

This protocol is ideal for individuals actively using GLP-1 medications, transitioning off, or focused on optimizing fat loss and lean mass retention. By targeting the systems that regulate hunger, stress, metabolism, and recovery, this protocol bridges therapeutic intervention with sustainable, long-term health.

Last updated: May 13, 2025

8 Nutrients

WP

Whey Protein

25000mg

Whey protein provides rapidly absorbed, high-quality amino acids that help preserve lean muscle mass, support satiety, and counteract protein deficiencies common with reduced appetite on GLP-1 medications—making it essential for metabolic balance and nutritional repletion. [1]

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HM

HMB

1500mg

HMB (beta-hydroxy beta-methylbutyrate) helps preserve lean muscle mass and prevent muscle loss often associated with reduced appetite or rapid weight loss on GLP-1 medications, supporting metabolic stability, strength, and functional outcomes during therapy. [2]

Cr

Creatine

5g

Creatine supports muscle energy production, strength, and lean mass preservation—critical during GLP-1-induced weight loss, which can include loss of muscle tissue. It also aids in cognitive function and cellular hydration, supporting overall performance and metabolic health. [3]

Fi

Fiber

9g

Fiber supports GLP-1 therapy by promoting satiety, stabilizing blood glucose, and improving gut motility, helping reduce common side effects like nausea and constipation. It also supports a healthy microbiome, which plays a role in metabolic and inflammatory balance. [4]

L-T

L-Theanine

100mg

Suntheanine® (a patented form of L-theanine) promotes calm focus and reduces stress-induced cortisol, which can support appetite regulation, digestion, and sleep quality—key areas impacted by GLP-1 therapies. It may also ease GI side effects linked to nervous system tension. [5]

B12

Vitamin B12

600mcg

B vitamins are essential cofactors in energy metabolism, nervous system function, and red blood cell production. For individuals on GLP-1 medications, adequate B vitamin intake may support metabolic balance, reduce fatigue, and help offset potential nutrient depletion associated with reduced food intake. [6]

D3

Vitamin D3

50mcg

Vitamin D and K2 work synergistically to support bone health, calcium balance, and cardiovascular function. For individuals on GLP-1 medications, this combination may help maintain nutrient absorption, musculoskeletal integrity, and metabolic balance during weight loss or appetite reduction. [7]

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Products

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Recommended for Whey Protein.
Servings
24.0
Price/serv
$2.71
From
$64.95
Format
scoop
Recommended for Creatine, HMB.
Servings
60.0
Price/serv
$1.50
From
$89.99
Format
scoop
Recommended for Fiber.
Servings
24.0
Price/serv
$2.10
From
$50.40
Format
scoop
Recommended for L-Theanine.
Servings
60.0
Price/serv
$0.40
From
$23.99
Format
capsule
Recommended for Vitamin B12, Vitamin D3.
Servings
30.0
Price/serv
$0.97
From
$29.01
Format
capsule
Recommended for Omega-3 fatty acids.
Servings
30.0
Price/serv
$0.63
From
$18.95
Format
softgel

Warnings

Do not use if pregnant, nursing, or under the age of 18. Not intended for individuals with known allergies to dairy or those with severe kidney disease.

Lifestyle Improvements

GLP-1 medications offer powerful metabolic benefits, but long-term success depends on how well the body is supported through the process. Lifestyle choices remain essential in preserving lean mass, promoting resilience, and minimizing side effects as metabolism shifts.

Prioritize protein at each meal—ideally 1 gram per pound of ideal body weight—to support muscle protein synthesis and prevent the lean tissue loss commonly associated with reduced appetite. This ensures metabolic rate and strength are maintained, even during calorie restriction.

Hydration with electrolytes is equally important. Sodium, magnesium, and potassium support energy levels, digestive regularity, and neurological function, all of which can be impacted during GLP-1 therapy. Begin the day with electrolytes to reduce fatigue and support fluid balance.

Incorporate daily movement, particularly resistance training 3–4 times per week, to reinforce muscular strength and metabolic efficiency. Complement this with fiber-rich foods—like leafy greens, chia seeds, and psyllium—to stabilize blood sugar, support digestion, and nourish the gut microbiome.

To counteract the physiological impact of stress, introduce nervous system regulation techniques such as deep breathing, meditation, or restorative movement. These practices help modulate cortisol and improve appetite signaling, sleep quality, and digestive function.

Aim for 7–9 hours of quality sleep per night to support hormonal health, recovery, and long-term weight management.

While GLP-1 medications initiate change, these lifestyle practices ensure the body adapts and thrives—creating a strong foundation for sustainable metabolic health.

Disclaimer

These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.

While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.

  1. Soares, A. L. S., Machado-Lima, A., Brech, G. C., Greve, J. M. D., Dos Santos, J. R., Inojossa, T. R., Rogero, M. M., Salles, J. E. N., Santarem-Sobrinho, J. M., Davis, C. L., & Alonso, A. C. (2023). The influence of whey protein on muscle strength, glycemic control and functional tasks in older adults with type 2 diabetes mellitus in a resistance exercise program: Randomized and triple blind clinical trial. International Journal of Environmental Research and Public Health, 20(10), 5891. https://doi.org/10.3390/ijerph20105891
  2. Wilkinson, D. J., Hossain, T., Hill, D. S., Phillips, B. E., Crossland, H., Williams, J., Loughna, P., Churchward-Venne, T. A., Breen, L., Phillips, S. M., Etheridge, T., Rathmacher, J. A., & Smith, K. (2013). Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. The Journal of Physiology, 591(11), 2911–2923. https://doi.org/10.1113/jphysiol.2013.253203
  3. Candow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019). Effectiveness of creatine supplementation on aging muscle and bone: Focus on falls prevention and inflammation. Journal of Clinical Medicine, 8(4), 488. https://doi.org/10.3390/jcm8040488
  4. Wu, S., Jia, W., He, H., Yin, J., Xu, H., He, C., Zhang, Q., Peng, Y., & Cheng, R. (2023). A new dietary fiber can enhance satiety and reduce postprandial blood glucose in healthy adults: A randomized cross-over trial. Nutrients, 15(21), 4569. https://doi.org/10.3390/nu15214569
  5. Higashiyama, A., Htay, H. H., Aoyama, M., & Juneja, L. R. (2011). Effects of L-theanine on attention and reaction time response. Journal of Functional Foods, 3(3), 171–178. https://doi.org/10.1016/j.jff.2011.03.009
  6. Tardy, A. L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020). Vitamins and minerals for energy, fatigue and cognition: A narrative review of the biochemical and clinical evidence. Nutrients, 12(1), 228. https://doi.org/10.3390/nu12010228
  7. van Ballegooijen, A. J., Pilz, S., Tomaschitz, A., Grübler, M., Verheyen, N., & Dekker, J. M. (2017). The synergistic interplay between vitamins D and K for bone and cardiovascular health: A narrative review. International Journal of Endocrinology, 2017, 7454376. https://doi.org/10.1155/2017/7454376
  8. Zivkovic, A. M., Telis, N., German, J. B., & Hammock, B. D. (2011). Dietary omega-3 fatty acids aid in the modulation of inflammation and metabolic health. California Agriculture, 65(3), 106–111. https://doi.org/10.3733/ca.v065n03p106