SuppCo Splash
Essential Immune Support

Protocol overview

Compare your current stack nutrients to the outlined protocol recommendations.

A well-functioning immune system is essential for overall health, protection against infections, and maintaining homeostasis in the body. The immune system is a complex network of cells, tissues, and signaling molecules that work together to identify and neutralize pathogens, regulate inflammation, and promote tissue repair. Supporting immune function through proper nutrition, lifestyle, and targeted supplementation can help optimize immune balance and enhance the body’s ability to adapt to various stressors.

A significant yet often overlooked aspect of immune health is the gut microbiome. The gut is home to nearly 70% of the body’s immune cells, making it a central hub for immune activity. A well-balanced gut microbiota plays a crucial role in training immune cells, regulating inflammatory responses, and preventing harmful pathogens from disrupting immune function. When gut health is compromised due to poor diet, stress, or environmental toxins, the immune system may become dysregulated, leading to increased susceptibility to infections, allergies, or chronic inflammation.

Several key nutrients and bioactive compounds play a central role in immune modulation. This protocol focuses on five well-researched components vitamin C, vitamin D, zinc, reishi mushroom, and immunoglobulin G (IgG) supplements. Each contributing uniquely to immune health through antioxidant support, cellular communication, pathogen defense, and immune regulation. Vitamin C and zinc are important for immune cell activation and reducing oxidative stress. Vitamin D plays a key role in immune signaling and supporting a balanced inflammatory response. Reishi mushroom contains bioactive polysaccharides that help modulate immune function, while IgG supplements support gut barrier integrity and promote immune surveillance.

This protocol integrates these essential nutrients to provide comprehensive immune support, helping to optimize immune function by addressing key mechanisms such as antioxidant protection, cellular defense, and gut-immune interactions in a constantly changing environment.

Last updated: May 8, 2025


5 Nutrients

D3

Vitamin D3

50mcg

Vitamin D interacts with immune cells, including macrophages, dendritic cells, and T lymphocytes, through vitamin D receptors. It plays a role in modulating inflammatory responses and supporting antimicrobial peptide production, and contributing to immune system regulation. [1]

See how your current
nutrient totals stack up

Log in or sign up
Zi

Zinc

15mg

Zinc is essential for immune function, supporting innate and adaptive responses. It plays a role in T-cell activation, cytokine regulation, and antioxidant defense. Zinc also contributes to maintaining immune cell integrity and function, influencing inflammatory balance and overall immune resilience. [2]

C

Vitamin C

1000mg

Vitamin C functions as a key antioxidant, contributing to cellular defense mechanisms and redox homeostasis. It plays a role in leukocyte function, collagen synthesis, and oxidative stress modulation, supporting physiological processes involved in immune surveillance and tissue integrity maintenance. [3]

Re

Reishi

157mg

Reishi (Ganoderma lucidum) is a medicinal mushroom rich in bioactive compounds such as polysaccharides, triterpenes, and beta-1,3/1,6-glucans, which may modulate immune function. Studies indicate that Reishi’s beta-glucans play a role in enhancing the activity of natural killer cells, T lymphocytes, and macrophages, contributing to a balanced and resilient immune response. [4]

IG

Immunoglobulin G

1500mg

Immunoglobulin G (IgG) supplements provide concentrated antibodies that may support immune balance by neutralizing pathogens and promoting gut barrier integrity. As the most abundant immunoglobulin, IgG helps regulate immune responses and may aid in reducing inflammatory burden and enhancing overall immune health. [5]


Welcome to SuppCo

Make Sense of Supplements

SuppCo is the world’s first app for building your Supplement Stack and meeting real health goals with Expert Protocols.

Download the app

Products

SuppCo does not participate in supplement affiliate programs. The links below are provided solely for your convenience.

Recommended for Vitamin D3.
Servings
60.0
Price/serv
$0.63
From
$37.99
Format
capsule
Recommended for Vitamin C.
Servings
250.0
Price/serv
$0.21
From
$52.20
Format
capsule
Recommended for Zinc.
Servings
60.0
Price/serv
$0.20
From
$12.00
Format
capsule
Recommended for Reishi.
Servings
30.0
Price/serv
$1.02
From
$30.71
Format
capsule
Recommended for Immunoglobulin G.
Servings
30.0
Price/serv
$2.63
From
$78.99
Format
scoop

Warnings

Do not take if you have known allergies to any of the ingredients. Avoid if you have an autoimmune condition without consulting a healthcare provider, as some ingredients may modulate immune activity. Do not take with immunosuppressive medications unless advised. If pregnant, nursing, or taking medications, consult a healthcare professional before use.


Lifestyle Improvements

In addition to targeted supplementation, lifestyle choices play a critical role in strengthening immune function and maintaining resilience against infections and environmental stressors. Implementing daily habits that support immune balance can enhance the effectiveness of your protocol and contribute to long-term wellness.

Prioritize Quality Sleep

Restorative sleep is essential for immune regulation and recovery. Aim for 7–9 hours per night to support optimal T-cell activity and cytokine production. Creating a consistent sleep routine, reducing blue light exposure before bed, and ensuring a dark, cool sleeping environment can significantly improve sleep quality.

Nourish with an Immune-Supportive Diet

A nutrient-dense diet rich in whole, unprocessed foods provides the building blocks for immune function.

  • Focus on antioxidant-rich foods: Berries, leafy greens, and citrus fruits provide vitamin C and polyphenols that help combat oxidative stress.
  • Include gut-supportive foods: Fermented foods like kimchi, sauerkraut, and kefir help maintain a healthy gut microbiome, which is closely linked to immune health.
  • Support metabolic balance: Avoid excess sugar and highly processed foods, which can promote inflammation and weaken immune resilience.

Engage in Regular Movement

Consistent exercise helps regulate immune function by enhancing circulation, reducing inflammation, and improving lymphatic flow.

  • Moderate-intensity exercise (30–45 minutes, 4–5x per week)—such as walking, resistance training, and yoga—supports immune resilience.
  • Avoid excessive high-intensity exercise without proper recovery, as it can suppress immune function temporarily.

Manage Stress to Reduce Immune Burden

Chronic stress increases cortisol levels, which can weaken immune defenses. Incorporating mindfulness practices, such as deep breathing, meditation, and journaling, can help regulate the nervous system and reduce inflammatory responses.

Optimize Hydration & Detoxification

Hydration is essential for lymphatic drainage and cellular function. Aim for at least half your body weight in ounces of water per day.

  • Herbal teas like ginger and green tea can provide additional immune-supportive compounds.
  • Contrast showers, sauna sessions, and dry brushing may support lymphatic detoxification and reduce immune burden.

By integrating these lifestyle foundations alongside targeted supplementation, you can enhance immune balance, resilience, and overall well-being. Small, consistent changes can have a profound impact on immune health in both the short and long term.


Disclaimer

These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.

While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.


  1. Ghaseminejad-Raeini, A., Ghaderi, A., Sharafi, A., Nematollahi-Sani, B., Moossavi, M., Derakhshani, A., & Sarab, G. A. (2023). Immunomodulatory actions of vitamin D in various immune-related disorders: A comprehensive review. Frontiers in Immunology, 14, 950465. https://doi.org/10.3389/fimmu.2023.950465
  2. Gammoh, N. Z., & Rink, L. (2017). Zinc in infection and inflammation. Nutrients, 9(6), 624. https://doi.org/10.3390/nu9060624
  3. Carr, A. C., & Maggini, S. (2017). Vitamin C and immune function. Nutrients, 9(11), 1211. https://doi.org/10.3390/nu9111211
  4. Jin, X., Ruiz Beguerie, J., Sze, D. M., & Chan, G. C. (2016). Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database of Systematic Reviews, 2016(4), CD007731. https://doi.org/10.1002/14651858.CD007731.pub3
  5. Ulfman, L. H., Leusen, J. H. W., Savelkoul, H. F. J., Warner, J. O., & van Neerven, R. J. J. (2018). Effects of bovine immunoglobulins on immune function, allergy, and infection. Frontiers in Nutrition, 5, 52. https://doi.org/10.3389/fnut.2018.00052