Natalie Crawford, M.D.’s
PCOS Nutrient Support
Protocol overview
Last updated: May 13, 2025
7 Nutrients
Folic Acid
400mcg
Folic acid helps lower elevated homocysteine levels often seen in PCOS, which may improve insulin sensitivity and cardiovascular health. It also supports ovulation and reproductive function by promoting DNA synthesis, methylation, and hormone regulation. (For a precise explanation of why folic acid is recommended instead of methylated folate, and additional information relating to the MTHFR gene, please review the Warning section later in the Protocol). [1]
See how your current
nutrient totals stack up
Log in or sign upVitamin D3
25mcg
Vitamin D supports healthy cell growth, helps regulate immune function and inflammation, and is essential for calcium absorption and bone mineralization. Adequate levels are important during midlife to maintain skeletal strength and support overall metabolic and immune health. [2]
Omega-3 fatty acids
300mg
Omega-3 fatty acids may help reduce inflammation, improve insulin sensitivity, and support hormonal balance in women with PCOS. Supplementation has been shown to lower triglycerides, regulate menstrual cycles, and reduce androgen levels, supporting metabolic and reproductive health. [3]
Coenzyme Q10
200mg
CoQ10 supports mitochondrial function and reduces oxidative stress in women with PCOS. It may improve insulin sensitivity, lower androgen levels, and support ovulation—making it beneficial for metabolic and reproductive health. [4]
Inositol
1000mg
Myo-inositol (MI) is important in cell communication and participates in insulin and gonadotropin signaling. MI is an antioxidant that improves insulin sensitivity and menstrual cycle regularity in PCOS. [5]
N-Acetylcysteine
1000mg
N-acetylcysteine (NAC), a derivative of natural amino acid L-cysteine, is a potent antioxidant that can reduce DNA damage. NAC can improve ovulation in PCOS, pregnancy rates in unexplained infertility, and decreases miscarriage rate. [6]
Melatonin
3mg
Melatonin supports sleep, acts as a powerful antioxidant, and may improve progesterone production and egg quality. However, doses over 3 mg can disrupt brain signaling, making lower,targeted doses safer and more effective for reproductive health. [7]

Make Sense of Supplements
SuppCo is the world’s first app for building your Supplement Stack and meeting real health goals with Expert Protocols.
Download the appProducts
SuppCo does not participate in supplement affiliate programs. The links below are provided solely for your convenience.
Warnings
If you are pregnant or undergoing fertility treatment, consult your medical provider. Use caution with metformin or anticoagulants, as some ingredients may enhance insulin sensitivity or affect blood clotting.
Many new prenatal vitamins have entered the market which have methylated folate instead of folic acid. Methylated folate is a downstream metabolite of folic acid. Although some people may have difficulty metabolizing folic acid (associated with a genetic mutation, MTHFR), it is very important to realize that only folic acid has been shown to prevent NTD (neural tube defects). Although methylated folate has been shown to result in sufficient blood folate levels, no study exists proving that methylated folate prevents neural tube defects or compares methylated folate vs folic acid. No study like this will ever exist because when something clearly prevents a bad outcome, like a birth defect, you would never allow a group of pregnant people to be at risk for this outcome when you could prevent it. I recommend you take at least 400 mcg of folic acid, in the form of folic acid. If you love a prenatal that has methylated folate, take an additional folic acid supplement. Methylated folate may help a small group of people who have problems metabolizing folic acid when they are not pregnant, but if you are trying to conceive, I recommend adding folic acid as well.
Lifestyle Improvements
Polycystic Ovary Syndrome (PCOS) is a complex hormonal condition, but the lifestyle changes you make can have a significant impact on how your body functions. In fact, for many patients, lifestyle interventions are the most powerful tool we have, especially when it comes to restoring ovulation, improving metabolic health, and supporting long-term wellness.
Let’s start with the basics: blood sugar balance. Even if you don’t have insulin resistance now, you may still be at higher risk due to PCOS. Prioritize complex, high-fiber carbohydrates like leafy greens, legumes, and whole grains. Avoid sugary drinks, ultra-processed foods, and excessive refined carbohydrates that can spike insulin and worsen androgen production. It’s not about cutting out all carbs, it’s about choosing the right ones that keep blood sugar stable and support hormone balance.
Focus on protein with every meal. Plant-based sources like lentils, tofu, and quinoa are great. If you eat animal protein focus on high-quality sources. Studies show that increasing servings of vegetable based protein over animal protein improve ovulation - so do not fear your plant based options. Protein helps regulate appetite and stabilize blood sugar. Omega-3 rich foods like salmon, walnuts, and chia seeds are also a great way to support inflammation and hormone signaling.
Movement matters. Exercise improves insulin sensitivity, reduces inflammation, and supports ovulation. If you’re burned out or under-fueled, too much high-intensity training can actually make things worse. A mix of strength training, walking, and restorative movement like yoga or Pilates is ideal. Find what feels good and supports consistency.
Sleep is your hormonal reset button. Aim for 7–9 hours per night, create a calming nighttime routine, and limit blue light before bed. Chronic sleep disruption can raise cortisol and worsen insulin resistance.
Minimize exposure to endocrine disruptors. That means ditch plastic food containers, avoid canned goods with BPA linings, and choose phthalate- and fragrance-free personal care products. These small shifts can reduce chemical exposures that mimic or interfere with hormone signaling.
Finally, be patient with your body. PCOS isn’t something to fix, it’s something to work with. And when we support the systems involved like metabolism, ovulation, inflammation, you can start to see real, lasting change.
Disclaimer
These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.
While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.
- Asemi, Z., Karamali, M., & Esmaillzadeh, A. (2014). Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. Molecular Nutrition & Food Research, 58(7), 1465–1473. https://doi.org/10.1002/mnfr.201400033
- Holick, M. F. (2007). Vitamin D deficiency. The New England Journal of Medicine, 357(3), 266–281. https://doi.org/10.1056/NEJMra070553
- Cussons, A. J., Watts, G. F., Mori, T. A., & Stuckey, B. G. A. (2009). Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: A randomized controlled trial employing proton magnetic resonance spectroscopy. The Journal of Clinical Endocrinology & Metabolism, 94(10), 3842–3848. https://doi.org/10.1210/jc.2009-0660
- Bader, S. A., Althanoon, Z. A., & Raoof, H. S. (2022). The metabolic effects of coenzyme Q10 in patients with polycystic ovary syndrome. Research Journal of Pharmacy and Technology, 15(3), 1157–1161. https://doi.org/10.52711/0974-360X.2022.00194
- Merviel, P., James, P., Bouée, S., Le Guillou, M., Rince, C., Nachtergaele, C., & Kerlan, V. (2021). Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies. Reproductive Health, 18(1), 13. https://doi.org/10.1186/s12978-021-01073-3
- Thakker, D., Raval, A., Patel, I., & Walia, R. (2015). N-acetylcysteine for polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled clinical trials. Obstetrics and Gynecology International, 2015, 817849. https://doi.org/10.1155/2015/817849
- Yong W, Ma H, Na M, Gao T, Zhang Y, Hao L, Yu H, Yang H, Deng X. Roles of melatonin in the field of reproductive medicine. Biomed Pharmacother. 2021 Dec;144:112001. doi: 10.1016/j.biopha.2021.112001. Epub 2021 Oct 6. PMID: 34624677