Natalie Crawford, M.D.’s
PMS Support
Protocol overview
Last updated: May 13, 2025
9 Nutrients
Folic Acid
400mcg
Hormonal shifts during the menstrual cycle can impact mood, energy, and cellular function. Folic acid supports healthy cell division, DNA repair, and methylation, key processes that help regulate neurotransmitters, and support tissue repair. (For a precise explanation of why folic acid is recommended instead of methylated folate, and additional information relating to the MTHFR gene, please review the Warning section later in the Protocol). [1]
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nutrient totals stack up
Log in or sign upVitamin D3
25mcg
Vitamin D supports healthy cell growth, helps regulate immune function and inflammation, and is essential for calcium absorption and bone mineralization. Adequate levels are important during midlife to maintain skeletal strength and support overall metabolic and immune health. [2]
Omega-3 fatty acids
600mg
Omega-3 fatty acids support cellular membrane integrity and help reduce inflammation, both of which are important during the hormonal fluctuations of the menstrual cycle. They may help in the reduction of of the severity of PMS symptoms. [3]
N-Acetylcysteine
1000mg
NAC is a powerful antioxidant that enhances glutathione production, helping to reduce oxidative stress and support cellular repair. It may also lower inflammation and improve insulin sensitivity, making it beneficial for metabolic and hormonal balance. [4]
Vitamin C
1000mg
Vitamin C supports immune function, collagen synthesis, and antioxidant defense. It may help reduce inflammation and oxidative stress while supporting neurotransmitter production. [5]
Vitamin E
536mg
Vitamin E is a fat-soluble antioxidant that protects cells from oxidative damage by neutralizing free radicals. It supports immune function, skin and cardiovascular health, and may help modulate inflammation, especially during periods of hormonal change or physical stress. [6]
Magnesium Glycinate
120mg
Magnesium is an essential mineral involved in muscle relaxation, hormone regulation, and neurotransmitter balance. For PMS, it may help relieve symptoms like cramps, irritability, and bloating by reducing inflammation, supporting mood stability, and easing muscular tension. [7]

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Warnings
If you are pregnant, breastfeeding, or taking anticoagulants, insulin-sensitizing medications, or sedatives, consult your healthcare provider before starting.
Many new prenatal vitamins have entered the market which have methylated folate instead of folic acid. Methylated folate is a downstream metabolite of folic acid. Although some people may have difficulty metabolizing folic acid (associated with a genetic mutation, MTHFR), it is very important to realize that only folic acid has been shown to prevent NTD (neural tube defects). Although methylated folate has been shown to result in sufficient blood folate levels, no study exists proving that methylated folate prevents neural tube defects or compares methylated folate vs folic acid. No study like this will ever exist because when something clearly prevents a bad outcome, like a birth defect, you would never allow a group of pregnant people to be at risk for this outcome when you could prevent it. I recommend you take at least 400 mcg of folic acid, in the form of folic acid. If you love a prenatal that has methylated folate, take an additional folic acid supplement. Methylated folate may help a small group of people who have problems metabolizing folic acid when they are not pregnant, but if you are trying to conceive, I recommend adding folic acid as well.
Lifestyle Improvements
When it comes to managing PMS, I always remind my patients that lifestyle plays a huge role—this is not just about hormones, it is about how your entire system is functioning. PMS symptoms like mood swings, fatigue, bloating, and breast tenderness are driven by hormonal fluctuations, particularly estrogen and progesterone, and how your body responds to them. Supporting your body through nutrition, exercise, and stress management can make a real difference.
Start with food. Aim for a balanced diet with plenty of fiber rich vegetables, whole grains, lean proteins, and healthy fats. Reducing processed foods, caffeine, and added sugars can help minimize blood sugar swings and inflammation that often worsen PMS symptoms. Magnesium rich foods like leafy greens, nuts, and seeds can help reduce cramps and support mood. Staying hydrated and limiting alcohol and salt may reduce bloating and fluid retention.
Exercise is one of my favorite prescriptions for PMS. Movement helps with circulation, mood, and metabolism. Regular moderate exercise such as brisk walks, yoga, or strength training can help reduce irritability, improve sleep, and support hormonal balance.
Sleep is also critical. Your hormones regulate on a rhythm, so disrupted or inadequate sleep can worsen PMS symptoms. Aim for seven to nine hours per night, and create a calming evening routine. If you find your sleep impacted in the luteal phase, magnesium or melatonin support may be helpful, but start with good sleep hygiene.
Stress plays a huge role in hormonal health. Cortisol and estrogen share some metabolic pathways, so when stress is high, PMS symptoms can feel amplified. Mindfulness, breath work, journaling, or even scheduling time for fun and rest can help your nervous system recalibrate.
And most importantly, track your cycle. Knowing when symptoms tend to appear gives you the power to prepare. You are not imagining it. If your symptoms are interfering with your quality of life, there are ways to support your body and feel better. You do not have to just push through.
Disclaimer
These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.
While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.
- Duthie, S. J., Narayanan, S., Brand, G. M., Pirie, L., & Grant, G. (2002). Impact of folate deficiency on DNA stability. The Journal of Nutrition, 132(8), 2444S–2449S. https://doi.org/10.1093/jn/132.8.2444S
- Holick, M. F. (2007). Vitamin D deficiency. The New England Journal of Medicine, 357(3), 266–281. https://doi.org/10.1056/NEJMra070553
- Mohammadi, M. M., Dehghan Nayeri, N., Mashhadi, M., & Varaei, S. (2022). Effect of omega-3 fatty acids on premenstrual syndrome: A systematic review and meta-analysis. Journal of Obstetrics and Gynaecology Research, 48(6), 1293–1305. https://doi.org/10.1111/jog.15217
- Thakker D, Raval A, Patel I, Walia R. N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials. Obstet Gynecol Int. (2015) 2015:817849. 10.1155/2015/817849
- Carr, A. C., & Maggini, S. (2017). Vitamin C and immune function. Nutrients, 9(11), 1211. https://doi.org/10.3390/nu9111211
- Traber, M. G., & Stevens, J. F. (2011). Vitamins C and E: Beneficial effects from a mechanistic perspective. Free Radical Biology and Medicine, 51(5), 1000–1013. https://doi.org/10.1016/j.freeradbiomed.2011.05.017
- Alizadeh, M., Karandish, M., Asghari Jafarabadi, M., Heidari, L., Nikbakht, R., Babaahmadi Rezaei, H., & Mousavi, R. (2021). Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Nutrition & Metabolism, 18(1), 57. https://doi.org/10.1186/s12986-021-00586-9
- Gholami, F., Mohammadbeigi, S., Rahimi, N., Shafiee, N., Saeedi, L., & Moosazadeh, K. (2022). Effect of melatonin supplementation on sleep quality: A systematic review and meta-analysis of randomized controlled trials. Journal of Neurology, 269(1), 205–216. https://doi.org/10.1007/s00415-020-10381-w
- Sangsefidi, Z. S., Yaghoubi, F., Hajiahmadi, S., & Hosseinzadeh, M. (2020). The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Food Science & Nutrition, 8(4), 1766–1776. https://doi.org/10.1002/fsn3.1492